Presenter: Sunil Pai, MD

Original Date: July 30, 2017

Inflammation in now recognized as a triggering mechanism related to almost every disease including cancer. Unfortunately, conventional medical options that lower inflammation from prescription pharmaceuticals such as TNF-alpha blockers and other biologics to over-the-counter NSAIDs all have Black Box Warnings and severe side effects. These medications help lower inflammatory mechanisms and provide only symptomatic relief. Many increase the chronic progression of the disease and only suppress the immune function, which leads to lowering the healing response and cause further side effects. CBD (cannabidiols) provide a new approach for the treatment of chronic inflammatory diseases without the side effects and may improve physiological healing responses.

For cancer, CBD is used not only for palliative effects, but also to decrease tumor growth by modulating key cell signaling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids inhibit angiogenesis and decrease metastasis in various tumor types. This lecture provides an understanding of cannabinoids as antitumor agents, focusing on their molecular mechanisms of action and opportunities for their use in combination therapy.

1.5 Pharmacology CEUs approved by OBNM