Presenter: Tom Fabian, PhD

Original Date: April 14, 2019

Research into the role of the microbiome in autoimmune disease has advanced rapidly in recent years, implicating microbiome-immune system interactions as critical factors may promote the development of autoimmunity. Microbial dysbiosis may lead to decreased immune tolerance and increased inflammatory activity, both of which are thought to be essential features of many autoimmune diseases. In addition, certain normal (commensal) microbes and pathogens can promote autoimmune reactivity via specific mechanisms, such as molecular mimicry and protein modification.

Current understanding of the role of microbiome-immune interactions will be discussed in the context of specific autoimmune diseases. Clinical applicability of the information presented will be illustrated through examples of functional testing results (including microbiome, immune and genomic tests), and microbiome-based therapeutic approaches. We will conclude with a brief discussion of the prospects for a paradigm shift in the understanding – and treatment - of autoimmune diseases.

2.0 General CEUs approved by OBNM